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Immune Checkpoint Inhibitors for Microsatellite Instability High Unresectable Obstructive Colon Cancer: A Report of
Goro Takahashi1, Akihisa Matsuda1, Takeshi Yamada1
1Department of Gastroenterological Surgery, Nippon Medical School Hospital, Tokyo, Japan.
Surgical Case Reports
|June 17, 2025
Summary
Immune checkpoint inhibitors (ICIs) offer a new approach for obstructive colon cancer (OCC) in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) tumors. These treatments can rapidly relieve symptoms and enable curative surgery, avoiding traditional decompression procedures.
Area of Science:
- Oncology
- Gastroenterology
- Immunotherapy
Background:
- Obstructive colon cancer (OCC) with metastases often presents with poor patient condition.
- Traditional treatment involves stoma creation and/or resection followed by chemotherapy.
- Immune checkpoint inhibitors (ICIs) have revolutionized treatment for DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer.
