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Role of cholecystectomy in hyperkinetic biliary dyskinesia: A systematic review and meta-analysis

Duyen Quach1, Kayla Nguyen1, Gabriella Tavera2

  • 1Department of Surgery, Graduate Medical Education, HCA Healthcare, Kingwood, TX, United States of America.

Surgery Open Science
|June 17, 2025
PubMed

Insights

Cholecystectomy effectively alleviates symptoms in patients with hyperkinetic biliary dyskinesia (HBD), a condition of gallbladder dysfunction. This surgical intervention shows promising results for select HBD patients, improving their quality of life.

Area of Science:

  • Gastroenterology
  • Surgical Innovation

Background:

  • Biliary dyskinesia involves reduced gallbladder ejection fraction (GEF).
  • Hyperkinetic biliary dyskinesia (HBD) is defined by GEF ≥80%.
  • The efficacy of cholecystectomy for HBD remains under investigation.

Purpose of the Study:

  • To investigate the effectiveness of cholecystectomy in managing HBD symptoms.
  • To synthesize current evidence on surgical outcomes for HBD.

Main Methods:

  • Systematic literature review and meta-analysis.
  • Inclusion of 14 studies with 416 HBD patients.
  • Random-effects model to calculate pooled risk ratios (RR) for symptom relief.

Main Results:

  • Overall pooled RR for symptom relief post-cholecystectomy was 3.72 (95% CI: 2.57-5.38).
  • Retrospective subgroup analysis showed an RR of 3.9 (95% CI: 2.57-5.92).
  • Moderate heterogeneity (I² = 30.01%) was observed across studies.

Conclusions:

  • Cholecystectomy demonstrates significant promise as an effective treatment for HBD.
  • Surgical intervention may provide substantial symptom relief for carefully selected HBD patients.
Abstract

Keywords:
Biliary hyperkinesiaCholecystectomyHyperkinetic biliary dyskinesiaHyperkinetic gallbladder

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