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Müller Muscle-Conjunctival Resection With Tarsectomy in Chronic Progressive External Ophthalmoplegia
Mehmet Serhat Mangan1, Emirhan Ozkul1,2, Ceyhun Arici3
1Division of Oculoplastic Surgery, Sadik Eratik Eye Institute, University of Health Sciences, Haydarpasa Numune Education and Research Hospital.
The Journal of Craniofacial Surgery
|June 17, 2025
Summary
Müller muscle-conjunctival resection with tarsectomy (MMCRT) successfully treated chronic progressive external ophthalmoplegia (CPEO) related ptosis in two patients. This surgical approach improved eyelid elevation without common complications, showing promise for future applications.
Area of Science:
- Ophthalmology
- Neurology
Background:
- Chronic progressive external ophthalmoplegia (CPEO) is a debilitating neuromuscular disorder.
- Progressive bilateral ptosis is a common and visually impairing symptom of CPEO.
- Existing surgical options for ptosis in CPEO patients carry risks of complications.
Purpose of the Study:
- To report the successful management of CPEO-related ptosis using a specific surgical technique.
- To evaluate the efficacy and safety of Müller muscle-conjunctival resection with tarsectomy (MMCRT) in CPEO patients.
Main Methods:
- Two cases of CPEO with progressive bilateral ptosis were treated.
- The surgical intervention involved Müller muscle-conjunctival resection with tarsectomy (MMCRT).
- Postoperative outcomes were assessed for eyelid elevation and complications.
Main Results:
- Both patients experienced significant improvement in eyelid elevation after MMCRT.
- No complications such as lagophthalmos or exposure keratopathy were observed.
- The surgical technique proved effective in managing ptosis in these CPEO cases.
Conclusions:
- Müller muscle-conjunctival resection with tarsectomy (MMCRT) is a promising surgical option for ptosis in CPEO.
- MMCRT offers potential advantages over alternative surgical methods for this patient population.
- Further research is warranted to confirm the long-term efficacy and safety of MMCRT for CPEO-related ptosis.
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