Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ASO Visual Abstract: Multidisciplinary Tumor Board Documentation-Assessing its Frequency, Quality, and Impact.

Annals of surgical oncology·2026

Same author

Multidisciplinary Tumor Board Documentation: Assessing its Frequency, Quality, and Impact.

Annals of surgical oncology·2026

Same author

Association between area deprivation index (ADI) and initial treatment among patients with desmoid tumors<sup>☆</sup>.

Surgical oncology insight·2026

Same author

Management of multifocal and metastatic retroperitoneal sarcoma: an updated consensus approach from the transatlantic australasian retroperitoneal sarcoma working group (TARPSWG).

Cancer treatment reviews·2026

Same author

Defining benchmark values for outcomes of comprehensive resection of primary retroperitoneal liposarcoma: a retrospective multicenter study.

EClinicalMedicine·2025

Same author

Variations in Outcomes of Surgical Oncology Fellowship Graduates Performing Hepatopancreatic Surgery in the United States Based on Fellowship Training Program.

Annals of surgical oncology·2025

Same journal

Revisiting the Immunological Landscape of Locoregional Therapies for Gastrointestinal Cancers: A Shift Toward Interventional Immuno-Oncology.

Current oncology reports·2026

Same journal

Anti-PD-1 Combinations: Triplets and Beyond.

Current oncology reports·2026

Same journal

Sacituzumab Tirumotecan Across Gynecologic Malignancies: One Target, Multiple Diseases.

Current oncology reports·2026

Same journal

Clusterin in Head and Neck Squamous Cell Carcinoma: Diagnostic, Prognostic, and Therapeutic Implications.

Current oncology reports·2026

Same journal

Cardiac Risk Without a Roadmap: Lack of Evidence-Based Guidance for Cardiovascular Toxicity of T-Cell Redirecting Therapies.

Current oncology reports·2026

Same journal

Current Understanding of CHIP's Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature.

Current oncology reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 19, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Circulating Biomarkers in Sarcoma.

Taylor P Williams¹, Valerie P Grignol²

¹Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, 460 W. 10 th Ave, Columbus, OH, 43210, USA.

Current Oncology Reports

|June 17, 2025

Summary

This summary is machine-generated.

Researchers are exploring novel circulating biomarkers, including circulating tumor DNA and micro-RNA, to improve the diagnosis and monitoring of diverse sarcoma subtypes. This review highlights ongoing efforts to find validated biomarkers for these rare cancers.

Keywords:

Biomarkers CtDNA Extracellular vesicles Sarcoma

More Related Videos

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Related Experiment Videos

Last Updated: Sep 19, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Area of Science:

Oncology
Biomarker Discovery
Molecular Diagnostics

Background:

Sarcomas encompass over 100 histologic subtypes, necessitating improved diagnostic and monitoring tools.
Current cancer detection methods require adjuncts for comprehensive patient management.
A critical need exists for easily retrievable circulating biomarkers in sarcoma patients.

Purpose of the Study:

To review the current progress in identifying and utilizing circulating biomarkers for sarcoma.
To describe various types of biomarkers and their testing modalities.
To explore the clinical utility of specific biomarkers in sarcoma diagnosis and monitoring.

Main Methods:

Literature review of current research on circulating biomarkers in sarcoma.
Analysis of genomic, proteomic, and metabolic biomarker candidates.
Examination of diagnostic and prognostic utility of identified biomarkers.

Main Results:

Genomic circulating biomarkers include circulating tumor DNA and micro-RNA.
Genomic expressions and oncogenes are highlighted for different sarcoma subtypes.
Investigational biomarkers include proteins, extracellular vesicles, and dysregulated metabolites.

Conclusions:

Soft tissue sarcomas currently lack a clinically validated circulating biomarker.
Ongoing research focuses on establishing genomic, proteomic, or metabolic biomarkers for sarcomas.
Circulating biomarkers hold promise for improved sarcoma evaluation, diagnosis, and treatment monitoring.