Related Experiment Video
Updated: Sep 19, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Step-wise and one-pot syntheses of the trisaccharide repeating unit of Proteus penneri 71 O-antigen
Tanmoy Halder1, Sunil K Yadav1, Somnath Yadav1
1Department of Chemistry & Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Dhanbad, 826004, Jharkhand, India.
Abstract:
Due to the importance of the capsular polysaccharides of bacterial pathogens from the perspective of eliciting human immune response and consequential developments of vaccines, they are important targets of synthetic efforts. Herein, we report the chemical synthesis of the trisaccharide repeating unit of the O-antigen capsular polysaccharide of Proteus penneri 71 by step-wise and one-pot approaches using suitably protected monosaccharide building blocks. A comparison of the yields of the products from the two strategies showed that the latter provided a higher yield (67%) than the former (56%).
Related Concept Videos
Peptidoglycan Synthesis
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Proteoglycans
Protein Glycosylation
Glycosylation occurs in...

