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Updated: Sep 19, 2025

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Toll-like receptors in B cells and obesity
Pai Wang1, Can Hou2, F Susan Wong3
1Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Section of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA.
Abstract:
Toll-like receptors (TLRs) play a pivotal role in both innate and adaptive immunity, primarily by detecting pathogen-associated molecular patterns (PAMPs) and orchestrating immune responses. Although TLR-driven activation of dendritic cells (DCs) and subsequent T cell differentiation are well characterized, the function of TLRs in B cells remains underexplored. In the context of obesity, excessive adipose tissue accumulation triggers chronic inflammation driven in part by activation of TLR signaling. This review explores the expression, function, and signaling mechanisms of TLRs in B cells, and emphasizes their role in modulating immune responses associated with obesity. Furthermore, we discuss how TLR-mediated inflammatory activity in B cells may contribute to metabolic dysregulation, and offer insights into the crosstalk between immune function and metabolic disease in obesity.
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