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Total Synthesis of the Conjugation-Ready Tetrasaccharide Repeating Unit of Acinetobacter baumannii MAR13-1452 (K125)
Haoyu Xue1, Yu Zhou1, Ke Feng1
1State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin, Nankai University, Tianjin 300350, China.
Abstract:
Acinetobacter baumannii is a highly drug-resistant pathogen that causes severe hospital infections and urgently requires new treatment strategies. Surface-exposed glycans of these bacteria have emerged as promising vaccine targets due to their immunogenic potential. Here, we report the first total synthesis of the tetrasaccharide repeating unit of Acinetobacter baumannii MAR13-1452 (K125). The presence of rare deoxy amino sugars and the exclusive 1,2-cis glycosidic linkages within the tetrasaccharide make its synthesis more challenging. A one-pot oligosaccharide assembly enabled efficient and facile synthesis of the target molecule.
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