Causal effects of office-associated behaviors on spinal stenosis: Two-sample Mendelian randomization study

Mendelian randomized studies can look for risk factors for disease. Spinal stenosis refers to a class of diseases that cause the shortening of the diameter of the spinal canal for various reasons, compressing the dural sac, spinal cord or nerve roots, resulting in a series of neurological dysfunctions such as pain, numbness, limb weakness, claudication, and urine and bowel disorders. The incidence of the disease is gradually increasing. Many office workers suffer from spinal diseases, and this study focused on the relationship between office-related behavioral features and spinal stenosis through Mendelian randomized analysis. In this study, we focused on direct Mendelian randomization (MR) analysis of office-related behavioral characteristics and spinal stenosis. The raw data for this study were taken from the Integrative Epidemiology Unit OpenGWAS project. Exposures: body mass index (BMI), nap during day, seated height, coffee, and Avoided activities or situations because of previous stressful experience in past month. Outcome factor: Spinal stenosis. Data filtering: Filter the results according to P value < 5e-08. After removing the linkage imbalance single nucleotide polymorphisms and removing the weak instrumental variable (filtering according to the F value > 10), then removing the confounding factors (P value = 1e-05, r2 = 0.8), and finally obtaining reliable Mendelian random analysis results. The results of two-sample MR analysis showed that sitting height was a protective factor for spinal stenosis, while BMI were risk factors for spinal stenosis. Through a two-sample MR analysis, we considered sitting height to be a protective factor for spinal stenosis, while BMI was a risk factor for spinal stenosis.