Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Water Intake01:25

Regulation of Water Intake

1.4K
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
1.4K
Physiology of the Genitourinary System III: Urine Concentration and Dilution01:20

Physiology of the Genitourinary System III: Urine Concentration and Dilution

49
The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...
49
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

39
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
39
Aging01:26

Aging

198
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
198
Regulation of Sodium and Potassium01:26

Regulation of Sodium and Potassium

898
The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
898
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

1.6K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in Differentiating Primary From Serious Secondary Headache.

European journal of neurology·2026
Same author

Neurofilament light chain and glial fibrillary acidic protein as potential early indicators of osmotic brain stress in hyponatremia and its correction.

European journal of endocrinology·2026
Same author

Prevalence and incidence of dysnatremia in European community-dwelling older adults-a secondary analysis of the DO-HEALTH trial.

European journal of endocrinology·2026
Same author

Neurophysin-I dynamics upon different pituitary provocation tests in healthy participants.

Endocrine connections·2026
Same author

Acromegaly and Cardiovascular Disease: Mechanisms, Clinical Impact, and Evolving Management.

Endocrine reviews·2026
Same author

Molecular imaging in pituitary neuroendocrine tumors: a narrative review of advances, challenges, and future perspectives.

European journal of endocrinology·2026
Same journal

Strengthening the metabolic alliance: exercise as an essential partner of obesity pharmacotherapy.

Nature reviews. Endocrinology·2026
Same journal

Reply to 'Post-thyrotoxicosis weight gain: time to stratify and treat?'

Nature reviews. Endocrinology·2026
Same journal

Post-thyrotoxicosis weight gain: time to stratify and treat?

Nature reviews. Endocrinology·2026
Same journal

Myostatin-targeting antibody protects lean mass during incretin-induced weight loss.

Nature reviews. Endocrinology·2026
Same journal

Macronutrient mixtures and interactions in health and disease.

Nature reviews. Endocrinology·2026
Same journal

Hepatic neurons and metabolically induced liver dysfunction.

Nature reviews. Endocrinology·2026
See all related articles

Related Experiment Video

Updated: Sep 19, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.5K

Hyponatraemia in ageing.

Sophie Monnerat1, Mirjam Christ-Crain1,2, Julie Refardt3,4,5

  • 1Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.

Nature Reviews. Endocrinology
|June 17, 2025
PubMed
Summary
This summary is machine-generated.

Hyponatraemia, common in older adults, increases risks of falls, fractures, and mortality. Correcting this electrolyte disorder can improve health outcomes, with SGLT2 inhibitors and protein supplements showing promise.

More Related Videos

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

3.2K
Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
08:25

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Published on: December 18, 2013

11.5K

Related Experiment Videos

Last Updated: Sep 19, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.5K
Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

3.2K
Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
08:25

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Published on: December 18, 2013

11.5K

Area of Science:

  • Geriatrics
  • Nephrology
  • Internal Medicine

Background:

  • Hyponatraemia is the most prevalent electrolyte disorder, particularly affecting older adults.
  • Risk factors include chronic diseases, polypharmacy, malnutrition, and increasing global warming.
  • Chronic hyponatraemia is linked to adverse outcomes like falls, fractures, cognitive decline, and mortality.

Purpose of the Study:

  • To review the consequences and common causes of hyponatraemia in the elderly.
  • To outline diagnostic strategies for hyponatraemia.
  • To discuss the benefits and limitations of current treatment options for hyponatraemia.

Main Methods:

  • This is a review article.
  • It synthesizes current literature on hyponatraemia.
  • Focuses on older adult populations and management strategies.

Main Results:

  • Correcting hyponatraemia is associated with improved clinical outcomes.
  • SGLT2 inhibitors and protein supplementation are effective treatment options for older adults.
  • Despite its prevalence, hyponatraemia is often underdiagnosed and undertreated.

Conclusions:

  • Hyponatraemia management is crucial for promoting healthy aging.
  • Effective diagnostic and therapeutic algorithms are needed.
  • Increased awareness and confidence in managing hyponatraemia are essential across medical specialties.