Affordable Cardiac Rehabilitation An Outreach Inter-Disciplinary Strategic Study (ACROSS) - Research Programme

Rod S Taylor1, Imran Bashir Chaudhry2,3,4, Mithila Faraque5

  • 1School of Health and Wellbeing, University of Glasgow College of Medical Veterinary and Life Sciences, Glasgow, Scotland, G12 8TA, UK.

NIHR Open Research
|June 18, 2025
PubMed

Insights

Cardiac rehabilitation (CR) is lacking in low-income countries. The ACROSS study co-develops an affordable, home-based CR program for heart disease and depression, evaluating its effectiveness and scalability in South Asia.

Area of Science:

  • Cardiology
  • Public Health
  • Health Services Research

Background:

  • Cardiac rehabilitation (CR) services and infrastructure are limited in low and middle-income countries (LMICs), hindering access to vital care.
  • Home-based CR programs offer a scalable and affordable solution to increase CR accessibility in LMICs.
  • The ACROSS study addresses the gap by focusing on multimorbidity of heart disease and co-existing depression/anxiety in LMICs.

Purpose of the Study:

  • To co-develop a culturally and contextually appropriate, affordable home-based CR program for individuals with heart disease and co-existing depression/anxiety.
  • To evaluate the acceptability, clinical effectiveness, and cost-effectiveness of this home-based CR program.
  • To determine the scalability and sustainability of the developed CR model in Bangladesh, India, and Pakistan.

Main Methods:

  • The study employs a phased approach through four work packages (WPs).
  • WP1 focuses on co-developing a culturally adapted home-based rehabilitation program addressing barriers and enablers.
  • WP2 conducts an external pilot to assess feasibility and acceptability, followed by a hybrid effectiveness-implementation randomized trial (WP3) and capacity building (WP4).

Main Results:

  • The ACROSS program aims to develop a clinically and cost-effective CR model for low-resource settings.
  • The study will provide data on the effectiveness and implementation of home-based CR for complex patient groups.
  • Anticipated benefits include substantial improvements in health and socio-economic outcomes for patients in the target regions.

Conclusions:

  • The ACROSS program seeks to establish a sustainable and effective home-based CR model for LMICs.
  • This initiative has the potential to significantly improve cardiovascular care and mental health support in resource-limited settings.
  • Successful implementation could lead to considerable health and socio-economic benefits for patients and communities in Bangladesh, India, and Pakistan.
Abstract

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