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Fibronectin Glomerulopathy: A First African Case Report
Abel Zemenfes Tsighe1, Helen Gebremedhin Gebreegziabhier1, Shephali Sharma2
1Nephrology Unit, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Case Reports in Nephrology and Dialysis
|June 18, 2025
Summary
Fibronectin glomerulopathy, a rare kidney disorder, was diagnosed in an Ethiopian patient, marking the first reported case in Africa. This highlights the need for improved diagnostic infrastructure in developing nations.
Area of Science:
- Nephrology
- Genetics
- Pathology
Background:
- Fibronectin glomerulopathy is a rare autosomal dominant kidney disorder caused by FN1 gene mutations.
- It typically presents with nephrotic range proteinuria and has been mainly reported in Asian and White populations.
Observation:
- A 17-year-old Ethiopian female presented with nephrotic syndrome, unresponsive to initial treatments.
- Kidney biopsy revealed characteristic fibronectin deposits, leading to the diagnosis.
Findings:
- This case represents the first documented instance of fibronectin glomerulopathy in Africa.
- The diagnosis was confirmed via immunohistochemistry, identifying extensive fibronectin deposition.
Implications:
- Diagnosing fibronectin glomerulopathy is challenging in developing countries due to limited diagnostic resources.
- Enhancing local pathology infrastructure is crucial for accurate diagnosis and management of rare kidney diseases.
Keywords:
FibronectinFibronectin glomerulopathyGlomerulopathy with fibronectin depositsNephrotic syndromeMore Related Videos
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