Yellow Urticaria Secondary to Platelet Transfusion

Area of Science:

• Dermatology
• Hematology
• Pathology

Background:

• Yellow urticaria (YU) is a rare variant of urticaria presenting with transient yellow rashes.
• It is typically associated with hyperbilirubinemia, often stemming from liver diseases.
• The yellow discoloration results from bilirubin precipitation in cutaneous elastin fibers due to vasodilation and extravasation.

Observation:

• This report details a rare case of YU occurring secondary to platelet transfusion.
• The patient presented with characteristic yellow wheals, confirmed by histopathology.
• The condition was successfully managed without adverse effects or recurrence.

Findings:

• The patient's YU responded rapidly to anti-hypersensitive and antihistamine treatments.
• Histopathological examination supported the diagnosis of YU.
• The prognosis for YU is generally favorable, with infrequent chronic or recurrent presentations.

Implications:

• This case expands the known causes of YU to include platelet transfusion reactions.
• It underscores the importance of considering YU in the differential diagnosis of yellow skin rashes.
• Effective treatment with conventional antihistamines suggests a histamine-mediated component, despite the bilirubin link.