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Primary Ovarian Malignant Melanoma: A Case Report.
Maria Zoi Bourou1, Theodoros Panoskaltsis1, Despoina Myoteri2
1Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens Medical School, Aretaieio University Hospital, Athens, GRC.
Cureus
|June 18, 2025
Summary
Primary ovarian melanoma (POM) is a rare ovarian cancer. This case report details a successful treatment of POM with adjuvant immunotherapy, showing promising outcomes for this aggressive malignancy.
Area of Science:
- Gynecologic Oncology
- Dermatology
- Pathology
Background:
- Primary ovarian melanoma (POM) is a rare and aggressive malignancy, often misdiagnosed due to clinical and histological similarities with other ovarian cancers.
- Distinguishing POM from more common metastatic ovarian melanoma is critical for appropriate management.
- The rarity and aggressive nature of POM present significant diagnostic and therapeutic challenges.
Observation:
- A 56-year-old woman presented with pelvic organ prolapse and an adnexal mass.
- The patient underwent a laparoscopically assisted vaginal hysterectomy and bilateral salpingo-oophorectomy.
- Histological examination confirmed primary ovarian melanoma.
Findings:
- The patient received adjuvant immunotherapy following surgical management.
- One year post-diagnosis, the patient shows no evidence of recurrence or distant metastasis.
- This case highlights a positive response to immunotherapy in primary ovarian melanoma.
Implications:
- Early and accurate diagnosis of POM is crucial for effective treatment.
- Adjuvant immunotherapy may represent a viable therapeutic option for primary ovarian melanoma.
- Further research into the management of this rare ovarian malignancy is warranted.
