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Trained immunity: A new player in cancer immunotherapy
Shu Li1,2, Yi Zou1, Austin McMasters3
1Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville School of Medicine, Louisville, United States.
Elife
|June 18, 2025
Summary
Trained immunity, a primitive immune response, enhances future reactions. This review explores its roles and therapeutic potential in various cancer types, detailing stimuli, mechanisms, and clinical applications.
Area of Science:
- Immunology
- Oncology
- Cellular Biology
Background:
- Immune memory was traditionally linked solely to adaptive immunity.
- Emerging evidence highlights innate immune system's capacity for 'trained immunity', enhancing responses after prior stimuli.
- Trained immunity is increasingly recognized for its role in diverse diseases, including cancer.
Purpose of the Study:
- To review the diverse roles of trained immunity in different cancer types.
- To summarize stimuli, molecular mechanisms, and clinical applications of trained immunity in oncology.
- To provide future perspectives on integrating trained immunity into cancer therapy.
Main Methods:
- Literature review of studies on trained immunity in cancer.
- Analysis of molecular mechanisms underlying trained immunity.
- Evaluation of clinical applications and therapeutic potential.
Main Results:
- Trained immunity plays multifaceted roles across various cancer types.
- Specific stimuli and molecular pathways are associated with trained immunity in cancer.
- Clinical applications in cancer therapy are emerging, with significant therapeutic potential.
Conclusions:
- Trained immunity represents a promising frontier in cancer therapy.
- Further research into stimuli and mechanisms can optimize its clinical integration.
- Harnessing trained immunity offers novel strategies for cancer treatment.
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