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Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
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Deep Infections After Open and Closed Fractures.

Michael Polmear1, Jennifer E Hagen1, Gregory M Schrank2

  • 1University of Florida, Gainesville, Florida.

The Journal of Bone and Joint Surgery. American Volume
|June 18, 2025
PubMed
Summary
This summary is machine-generated.

Surgical site infections (SSIs) show high culture positivity rates. Open fractures have more gram-negative bacteria and polymicrobial infections, leading to earlier infection times. Deep-tissue cultures are recommended for suspected SSIs.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Orthopedic Surgery

Background:

  • Surgical site infections (SSIs) are a significant concern in patient care.
  • Understanding the microbial landscape of SSIs is crucial for effective treatment.

Purpose of the Study:

  • To analyze culture and speciation results from patients with surgical site infections (SSIs).
  • To compare microbial findings between open and closed fractures in SSI cases.

Main Methods:

  • Deep or organ tissue samples were collected from patients with suspected SSIs for microbial culture.
  • Culture positivity rates and microbial species were quantified.
  • Statistical analyses, including Z-tests for proportions and hazard ratios, were used to compare outcomes between fracture types and infection characteristics.

Main Results:

  • A high culture positivity rate of 96.7% was observed in 484 SSI cases.
  • Open fractures showed a higher likelihood of polymicrobial infections (47.8%) compared to closed fractures (36.8%).
  • Staphylococcus aureus was the most common microbe. Gram-negative infections and polymicrobial infections were associated with a shorter median time to infection.

Conclusions:

  • Deep-tissue cultures are highly effective in identifying pathogens in suspected SSIs.
  • Open fractures present a greater risk of polymicrobial infections and earlier onset.
  • Clinicians should consider the potential for polymicrobial infections and earlier infection timelines, particularly in open fractures.