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Updated: Sep 19, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Photolabile Linkers for Solid-Phase Synthesis of Oligosaccharides
Yan-Ting Kuo1,2,3, Kim Le Mai Hoang2, Peter H Seeberger4,5
1Department of Biomolecular System, Max Planck Institute for Colloids and Interfaces, Potsdam, Germany.
None:
Photolabile linkers are chemically very stable and can be cleaved under mild conditions without destructive reactions on target molecules. o-Nitrobenzyl-based linkers are widely used in solid phase synthesis. Recently, our group developed several o-nitrobenzylic-based photolabile resins retaining different modifications at reducing-end of glycans after photocleavage. Here, we described the synthesis of three different o-nitrobenzylic derivatives and the immobilization of linkers on commercial Merrifield resin. Subsequently, detailed procedures of loading determination and photocleavage are presented.
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