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Longitudinal associations between self-reported exercise levels and cognition in ADAD
Kelsey R Sewell1,2, James D Doecke3, Ralph N Martins4,5,6
1Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
Summary
Regular exercise is linked to better cognitive function in individuals with autosomal dominant Alzheimer's disease (ADAD) mutations. However, AD-related pathways may reduce exercise engagement before cognitive symptoms appear.
Area of Science:
- Neuroscience
- Genetics
- Public Health
Background:
- Autosomal dominant Alzheimer's disease (ADAD) mutations represent a unique model for studying Alzheimer's disease (AD) pathogenesis.
- Understanding factors influencing cognition in ADAD mutation carriers is crucial for developing preventative strategies.
Purpose of the Study:
- To investigate the longitudinal relationship between self-reported exercise and cognitive function in individuals with ADAD mutations.
- To examine potential sex-based moderation of exercise-cognition associations.
- To compare changes in exercise engagement over time between ADAD mutation carriers and non-carriers.
Main Methods:
- A cohort of 491 participants, including ADAD mutation carriers and non-carriers from the Dominantly Inherited Alzheimer Network, was studied.
- Participants reported average leisure-time exercise over the past 12 months.
- Longitudinal cognitive assessments were performed.
Main Results:
- Higher baseline exercise was associated with better cognitive performance over time.
- No significant moderation by sex was observed.
- ADAD mutation carriers exhibited a decline in exercise engagement in the years preceding symptom onset compared to non-carriers.
Conclusions:
- Self-reported exercise is linked to preserved cognitive function in individuals with ADAD mutations.
- Evidence suggests that AD-related biological pathways might influence exercise participation prior to clinical symptom manifestation.
- A potential bidirectional relationship between exercise and AD risk is indicated.
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