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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

Updated: Sep 19, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Recent Advances in Ablative Therapies for HCC.

Arun Gupta1, Raghav Seth1, Ajit Yadav1

  • 1Department of Interventional Radiology, Sir Ganga Ram Hospital, New Delhi, India.

Journal of Clinical and Experimental Hepatology
|June 19, 2025
PubMed
Summary

Hepatocellular carcinoma (HCC), a common cancer, often requires less invasive treatments. Image-guided ablation offers a proven, effective option for patients unsuitable for surgery or transplantation.

Keywords:
Irreversible electroporation therapyablation techniquescarcinoma hepatocellularcryosurgeryradiofrequency ablation

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Area of Science:

  • Oncology
  • Hepatology
  • Interventional Radiology

Background:

  • Hepatocellular carcinoma (HCC) is a significant global health concern, ranking sixth in incidence and third in cancer mortality worldwide.
  • Early-stage HCC management typically involves surgical resection, liver transplantation, or percutaneous image-guided ablation.
  • Many patients are ineligible for liver transplantation or surgical resection, necessitating alternative treatments.

Purpose of the Study:

  • To review current data on percutaneous ablation for HCC.
  • To discuss the latest techniques in image-guided tumor ablation for hepatocellular carcinoma.

Main Methods:

  • Literature review of existing studies and clinical data.
  • Analysis of current guidelines and technological advancements in HCC ablation.

Main Results:

  • Percutaneous image-guided ablation is an accepted curative option for HCC, especially for patients ineligible for other treatments.
  • This minimally invasive approach demonstrates proven efficacy in managing HCC.
  • Latest techniques enhance the effectiveness and applicability of ablation therapies.

Conclusions:

  • Image-guided percutaneous ablation is a vital, less invasive treatment modality for eligible HCC patients.
  • The review highlights the evolving landscape and efficacy of ablation techniques in HCC management.