Convergent synthesis of coumarin C3-C4-fused fluorogenic quinoline scaffolds via aldehyde activation using in situ
Ranjithkumar Ganesan1, Sriraghavan Kamaraj1
1Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil-Nadu 632014, India. sriraghavan.k@vit.ac.in.
Abstract:
Herein, we report an efficient route for the construction of diversely substituted coumarin C3-C4-fused quinoline from pre-functionalized 4-azido-3-formylcoumarin using various aromatic/heterocyclic amines in excellent yield with a focus on application-oriented substrate scope. This protocol provides straightforward synthesis of fluorogenic coumarin-fused quinoline scaffolds through aldehyde activation using in situ generated HN3 with excellent atom economy and without any secondary product formation.
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