Leptin for Obesity: Previous Failures, Promising Future
Avraham Marcucci1, Jamie Mullally2, William H Frishman1
1From the Department of Internal Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY.
Abstract:
The history of obesity research has been highlighted by the discovery of leptin, a hormone crucial for regulating energy balance. Initially identified in 1950 in mice prone to obesity and diabetes, leptin continues to play a crucial role in our understanding of the physiology of obesity. Recombinant leptin showed promise in reducing weight in leptin-deficient mice and humans, but its effectiveness was limited by leptin resistance in diet-induced obesity. Combination therapies with amylin showed enhanced weight loss, but challenges with antibody development arose. Recent studies have explored combining leptin with glucagon-like peptide-1 receptor agonists, showing potential for reducing food intake and body weight by targeting specific neurons in the hypothalamus.
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Obesity
Regulation of Food Intake
Insulin: The Receptor and Signaling Pathways
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Dipeptidyl Peptidase 4 Inhibitors


