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Updated: Sep 19, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Liquid biopsy for microbiome profiling through nucleotide analysis.

Ilana Kolodkin-Gal¹, Milana Frenkel-Morgenstern¹

¹Scojen Institute for Synthetic Biology, Dina Recanati School of Medicine, Reichman University, Herzliya, Israel.

Trends in Biotechnology

|June 19, 2025

Summary

This summary is machine-generated.

Liquid biopsy analyzes bodily fluids to study the microbiome, offering a noninvasive method for pathogen detection and disease insights. This approach aids in real-time monitoring of microbial shifts for diagnostics and personalized medicine.

Keywords:

cell-free DNA chimeric RNA liquid biopsy microbiome pathogens sequencing vesicles

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Last Updated: Sep 19, 2025

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Area of Science:

Microbiology
Biotechnology
Medical Diagnostics

Background:

Liquid biopsy is an emerging technique for analyzing microbial communities in biological fluids.
It offers a noninvasive alternative to traditional sampling methods for microbiome studies.
Understanding microbiome dynamics is crucial for diagnosing and managing various health conditions.

Purpose of the Study:

To review the emerging role and applications of liquid biopsy in microbiome analysis.
To highlight its potential in infection detection, cancer diagnostics, and personalized medicine.
To emphasize its utility in real-time monitoring of microbial community shifts.

Main Methods:

Review of current literature on liquid biopsy for microbiome analysis.
Analysis of clinical applications in infectious diseases, oncology, and gastroenterology.
Discussion of technological advancements enabling noninvasive microbiome sampling.

Main Results:

Liquid biopsy provides insights into pathologies and enables unbiased pathogen detection.
Noninvasive sampling offers rapid turnaround times for diagnostic results.
Emerging clinical applications demonstrate its potential in personalized medicine.

Conclusions:

Liquid biopsy is a revolutionary tool for microbiome exploration and infection diagnostics.
It facilitates real-time monitoring of microbial shifts, advancing tailored medicine.
This noninvasive approach holds significant promise for future healthcare applications.