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Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Updated: May 7, 2026

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

High-performance nanobiosensing technologies for future diagnostic needs.

Aldo I Martinez-Banderas¹, Anas Malki², Thomas Froehlich²

¹Roche Diagnostics GmbH, Penzberg, Germany; Present address: DIOPTIC GmbH, Weinheim, Germany.

Trends in Biotechnology

|June 19, 2025

Summary

This summary is machine-generated.

This review covers emerging nanobiosensor technologies for healthcare, detailing their performance in detecting nucleic acids, proteins, and small molecules for disease screening and monitoring.

Keywords:

biosensors multimodality multiplexing sensitivity

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Area of Science:

Biomedical Engineering
Nanotechnology
Medical Diagnostics

Background:

Diagnostic sensor technologies are crucial for healthcare, including disease screening, detection, and therapy monitoring.
Nanobiosensor technologies have advanced significantly, utilizing diverse principles like electrical, magnetic, mass-based, and photonic signal transduction.

Purpose of the Study:

To provide an overview of recent and emerging nanobiosensing transduction technologies.
To assess and compare their performance, multimodality, multiplexing capabilities, portability, and throughput.
To elaborate on current and potential medical applications of nanobiosensors.

Main Methods:

Review of recent and emerging nanobiosensing transduction technologies.
Analysis of reported quantification capabilities for nucleic acids, proteins, and small molecules.
Comparative assessment of performance metrics, including multimodality, multiplexing, portability, and throughput.

Main Results:

Overview of diverse nanobiosensing transduction methods (electrical, magnetic, mass-based, photonic).
Illustration of quantification capabilities for various biomarkers.
Comparison of nanobiosensors based on key performance indicators.

Conclusions:

Nanobiosensors offer significant potential for disease screening, detection, and therapy monitoring.
Further research is needed to overcome fundamental limitations like the diffusion limit for enhanced applications.
Future opportunities lie in improving performance, multimodality, and throughput for clinical translation.