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Fibril Structure of Desiccation-Protective Tardigrade Protein CAHS-8

Anas Malki1,2, Jean-Marie Teulon1, Emmi A Mikkola1

  • 1Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.

Angewandte Chemie (International Ed. in English)
|December 31, 2025
PubMed
Summary

Cytosolic Abundant Heat-Soluble (CAHS) proteins protect tardigrades from desiccation. The crystal structure of CAHS-8 fibrils reveals an atypical coiled-coil dimer assembly crucial for cell survival under stress.

Keywords:
FibreIntrinsically disordered proteinStructural biologyTardigradeX‐ray diffraction

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