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Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally

Gaurav P Kudalkar1, Florian Leidner2, Nivesh Kumar1

  • 1Department of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA.

Angewandte Chemie (International Ed. in English)
|June 19, 2025
PubMed

Keywords:
Clostridium acetobutylicum alcohol dehydrogenase (CaADH)Dynamic reductive kinetic resolution (DYRKR)Flexible loopHalogen bondingTaxotere side chains

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