Related Experiment Video
Updated: Sep 18, 2025
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
De novo post-COVID-19 chronic pain: a piece of information about risk factor and clinical features
Fernanda de Toledo Goncalves1, Isabela Firigato1, Anne Victorio Pessotto1
1LIM40-Departamento de Medicina Legal, Bioetica, Medicina do Trabalho e Medicina Fisica e Reabilitacao da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Objective:
SARS-CoV-2 infection has been linked with chronic pain, leading to disability and affecting quality of life. Single nucleotide polymorphisms in the Mu-opioid receptor gene, which influence pain intensity, perception, and analgesic response, may contribute to chronic pain development. We compared patients with de novo post-COVID-19 pain with individuals with chronic pain due to knee osteoarthritis (OA) and investigated whether opioid receptor Mu 1 (OPRM1) polymorphisms (rs1799971; rs1799972) were associated with de novo pain.
Methods:
Seventy-one post-COVID-19 pain patients, 113 patients with knee OA, and 157 controls without chronic pain were evaluated using physical examinations, pain assessments, and standardized questionnaires addressing quality of life, cognitive function, emotional status, and sociodemographic data. Opioid receptor Mu 1 polymorphisms were genotyped using the TaqMan Real-Time qPCR. Pain characteristics were compared using the Χ 2 test, while Fisher exact test and logistic regression were applied to assess risk factors and calculated odds ratios.
Results:
Although chronic pain intensity was similar between the 2 cohorts, de novo post-COVID-19 pain patients reported higher opioid intake, increased pain sensitivity, and more catastrophic thinking. By contrast, patients with knee OA provided clearer descriptions of their pain and exhibited higher levels of depression and cognitive impairment. Musculoskeletal disorders and lower pain pressure threshold were significantly associated with post-COVID-19 pain development. Although the frequencies of OPRM1-mutated alleles varied between cases and controls, no significant associations were observed.
Conclusion:
De novo post-COVID-19 pain exhibits different clinical features compared with chronic pain conditions, underscoring the need for tailored management and treatment strategies in this postpandemic scenario.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:19Pericarditis II: Clinical Features and Diagnostic Tests
01:25Endocarditis II: Clinical Features of Infective Endocarditis
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:25Analgesia and Pain Management