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Parkinson's Disease: Treatment

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Related Experiment Video

Updated: Sep 18, 2025

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

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Rectal Administration of Carbidopa/Levodopa.

Andrew Guthrie^1,2, Joshua King¹, Ashley Casey³

¹Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, LA.

Ochsner Journal

|June 20, 2025

Summary

Rectal carbidopa/levodopa offers an effective alternative for Parkinson disease patients unable to take oral medication. This route can successfully manage Parkinson symptoms when oral intake is not feasible.

Keywords:

Administration–rectal Parkinson disease carbidopa–levodopa drug combination

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Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Published on: October 26, 2010

Related Experiment Videos

Last Updated: Sep 18, 2025

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Published on: October 26, 2010

Area of Science:

Neurology
Pharmacology

Background:

Parkinson disease management relies heavily on carbidopa/levodopa.
Oral administration challenges arise in certain clinical scenarios, necessitating alternative delivery methods.

Observation:

A 90-year-old male with Parkinson disease experienced confusion and agitation.
Enteric access was not obtainable for this patient.

Findings:

Rectal administration of carbidopa/levodopa was performed.
A notable reduction in Parkinson disease symptoms was observed following rectal administration.

Implications:

Rectal carbidopa/levodopa presents a viable alternative route for Parkinson disease patients.
This method can be effective in preventing complications when oral medication is not possible.