Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The gastric mucosal barrier. Component control.

G L Kauffman

    Digestive Diseases and Sciences
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    The gastric mucosal barrier maintains a significant hydrogen ion (H+) gradient, crucial for stomach health. This barrier limits acid back-diffusion, protecting the stomach lining from damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Helicobacter pylori and the gastroduodenal mucosa.

    Surgery·2001
    Same author

    Duodenal ulcer disease: treatment by surgery, antibiotics, or both.

    Advances in surgery·2000
    Same author

    Giant fundic polyp complicating attenuated familial adenomatous polyposis.

    The American journal of gastroenterology·2000
    Same author

    Pretreatment with SR48692 has different effects on central neurotensin-induced gastric mucosal defense and inhibition of gastric acid secretion in rats.

    Brain research·1998
    Same author

    Mesolimbic expression of neurotensin and neurotensin receptor during stress-induced gastric mucosal injury.

    The American journal of physiology·1998
    Same author

    Stress, the brain, and the gastric mucosa.

    American journal of surgery·1997
    Same journal

    Standardizing Transition of Care for Adolescents with Inflammatory Bowel Disease: The Need for a Unified Approach.

    Digestive diseases and sciences·2026
    Same journal

    Rapid Gastric Emptying: Insights from a Large Cohort Study on a Controversial Disorder.

    Digestive diseases and sciences·2026
    Same journal

    Readability, Quality, Understandability, and Actionability of ChatGPT Generated GI Patient Education Versus AGA Patient Center.

    Digestive diseases and sciences·2026
    Same journal

    Distinctive Endoscopic Ultrasound Features of Pancreatic Adenosquamous Carcinoma: A Propensity Score-Matched Analysis.

    Digestive diseases and sciences·2026
    Same journal

    FIGThe Efficacy and Safety of Clip-Assisted Endoscopic Cyanoacrylate Injection for Gastric Varices: A Systematic Review and Meta-Analysis.

    Digestive diseases and sciences·2026
    Same journal

    Gastroscopic Removal of a Duodenal Foreign Body in a 94-Year-Old Patient.

    Digestive diseases and sciences·2026
    See all related articles

    Area of Science:

    • Gastroenterology
    • Physiology
    • Biochemistry

    Background:

    • The gastric mucosal barrier is vital for maintaining stomach lining integrity.
    • It regulates hydrogen ion (H+) and electrolyte flux between the lumen and mucosa.
    • Its functional integrity is assessed by H+ diffusion, Na+ flux, and transmucosal potential difference (PD).

    Purpose of the Study:

    • To describe the functional aspects of the gastric mucosal barrier.
    • To explore the mechanisms underlying the maintenance of the H+ gradient.
    • To investigate the role of various agents and endogenous compounds in barrier function.

    Main Methods:

    • Assessing H+ and Na+ diffusion across the gastric epithelium.
    • Measuring transmucosal potential difference (PD).

    Related Experiment Videos

  • Evaluating the effects of luminal agents (aspirin, bile salts, ethanol) and prostanoids on barrier function.

    • Main Results:

    • The gastric mucosal barrier maintains a 10^5 H+ concentration gradient.
    • Luminal irritants increase cation flux and decrease PD.
    • Prostanoids can attenuate the effects of irritants, but the role of endogenous prostaglandins is debated.

    Conclusions:

    • The gastric mucosal barrier is a critical physiological defense mechanism.
    • It minimizes H+ back-diffusion, protecting the gastric epithelium.
    • While its exact composition is debated, its functional integrity is well-established.