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tRF-5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress

Xing-Xing Zhu1, Han Li1, Shuang-Feng Zi1

  • 1Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 20, 2025
PubMed
Summary

Secretory autophagosomes (SAPs) from inflamed macrophages worsen acute respiratory distress syndrome (ARDS) by activating endothelial cells. A specific molecule, tRF-5004b, within these SAPs drives this activation, indicating its potential as a therapeutic target for ARDS.

Keywords:
ARDSendothelial cellssecretory autophagosomestRNA‐derived small RNAs

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