Topical lifitegrast therapy for dry eye disease

Area of Science:

• Ophthalmology
• Pharmacology

Background:

• Dry eye disease (DED) is a prevalent ocular surface condition.
• Current treatments for DED have limitations in efficacy and safety.

Purpose of the Study:

• To evaluate the effectiveness and safety of topical lifitegrast for treating dry eye disease.
• To compare lifitegrast therapy (alone or with artificial tears) against placebo, artificial tears alone, or no treatment.

Main Methods:

• This is a protocol for a Cochrane Review.
• Systematic review methodology will be employed to synthesize evidence.

Main Results:

• Results are pending the completion of the systematic review.
• Evidence synthesis will focus on clinical outcomes and adverse events.

Conclusions:

• Conclusions will be drawn based on the synthesized evidence regarding lifitegrast's role in DED management.
• Findings will inform clinical practice and future research directions.