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Esculin delivery system based on phospholipid complex technology: research on solubility optimization and
Jiale Mao1, Lixin Yi2,3, Honghui Zhao1
1Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, China.
Natural Product Research
|June 20, 2025
Summary
This study developed an esculin phospholipid complex (ES-PC) to improve esculin
Area of Science:
- Food Science and Technology
- Materials Science
- Pharmaceutical Sciences
Background:
- Esculin (ES) exhibits antibacterial properties but suffers from poor solubility and bioavailability, hindering its practical applications.
- Developing effective delivery systems is crucial for enhancing the utility of poorly soluble compounds like esculin.
Purpose of the Study:
- To prepare and characterize an esculin phospholipid complex (ES-PC) to improve esculin's solubility and bioavailability.
- To evaluate the efficacy of ES-PC in a composite film for preserving pork.
- To explore a novel drug delivery system for insoluble compounds.
Main Methods:
- Esculin phospholipid complex (ES-PC) was synthesized using the solvent evaporation method.
- Characterization involved Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), and 1H-Nuclear Magnetic Resonance (1H-NMR).
- Solubility, hydrophilicity (octanol-water partition coefficient), and dissolution rates were assessed. Efficacy was tested in a pork preservation composite film.
Main Results:
- The ES-PC exhibited an amorphous structure stabilized by intermolecular forces.
- ES-PC showed a 13.8-fold increase in water solubility and a 7.3-fold increase in n-octanol solubility compared to ES.
- ES-PC demonstrated a cumulative dissolution rate exceeding 85% within 4 hours and effectively inhibited bacterial growth, maintained low pH and TVB-N values, extending pork shelf-life.
Conclusions:
- The developed esculin phospholipid complex (ES-PC) significantly enhances esculin's solubility, dissolution, and bioavailability.
- ES-PC incorporated into a composite film effectively preserves pork by inhibiting bacterial growth and maintaining quality parameters.
- This study presents a viable strategy for developing advanced delivery systems for poorly soluble drugs, broadening their application scope.
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