Related Experiment Video
Updated: Aug 14, 2026

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap
Published on: January 16, 2014
Effect of atenolol on car drivers in a prolonged stress situation
Abstract:
The effects of atenolol were investigated in car drivers participating in an amateur car rally. Atenolol or placebo were administered to two groups of 20 crews (driver and assistant) in this double-blind randomized trial. When compared with placebo, there was no deterioration in subjective appraisal of alertness and reaction ability in subjects given atenolol, and stress symptoms were markedly reduced. When compared with previous experience, the incidence of improved subjective appraisal of general driving ability was higher with atenolol (30 reports) than with placebo (5 reports). Furthermore the incidence of unchanged or worsened driving ability was significantly higher (p less than 0.001) with placebo (34 reports) than with atenolol (9 reports). At the end of the rally (16 hours after administration) subjects receiving atenolol 50 mg had significant reductions in heart rate (p less than 0.001), diastolic pressure (p less than 0.01), and systolic pressure (p less than 0.01) when compared with placebo.
Related Concept Videos
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
Antihypertensive Drugs: Action of β1 Blockers
Antihypertensive Drugs: Types of β-Blockers
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Introduction to Stress and Lifestyle
Psychological Responses to Stress

