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Updated: Sep 18, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
Published on: March 5, 2022
The emerging role of m5C modification in viral infection
1Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China; Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Abstract:
5-Methylcytosine (m5C) modification is a dynamic and reversible post-transcriptional process that has garnered significant attention due to its regulatory role in viral infections and host innate immune responses. Advances in m5C detection technologies have spurred research into its influence on viral infection pathways. Recent studies indicate that m5C modification can affect viral infections by modulating innate immune signaling pathways. Furthermore, viruses have developed strategies to exploit m5C modification for evading host immunity. Despite these findings, the exact regulatory mechanisms of m5C during viral infections and its impact on host immunity remain incompletely understood. Investigating m5C modifications and the enzymes associated with these changes may provide deeper insights into the epigenetic underpinnings of viral infections. This review aims to review the dual roles of m5C in various viral infections, emphasizing its potential as a target for antiviral interventions, given its pivotal role across numerous viruses.
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