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An in vitro measurement of bleeding time
The Journal of Laboratory and Clinical Medicine
|June 1, 1977
Summary
A new in vitro machine bleeding time (MBT) test accurately measures hemostatic abnormalities, similar to template bleeding time. This reproducible test is sensitive to conditions like thrombocytopenia and von Willebrand
Area of Science:
- Hematology
- Clinical Diagnostics
- Biomedical Engineering
Background:
- Assessing hemostasis is crucial for diagnosing bleeding disorders.
- Existing methods like template bleeding time have limitations.
- Need for a reproducible in vitro bleeding time test.
Purpose of the Study:
- To describe a novel in vitro method for measuring bleeding time.
- To evaluate the performance of the machine bleeding time (MBT) test.
- To compare MBT with existing hemostatic assays.
Main Methods:
- Development of the machine bleeding time (MBT) assay.
- In vitro testing of blood samples.
- Evaluation of MBT sensitivity to various hemostatic challenges.
Main Results:
- The MBT test is not affected by heparin.
- MBT detects hemostatic abnormalities similar to template bleeding time.
- MBT is sensitive to thrombocytopenia, aspirin, and von Willebrand's disease.
- The test demonstrates reproducibility for serial measurements.
Conclusions:
- The machine bleeding time (MBT) offers a reliable in vitro method for assessing hemostasis.
- MBT is a sensitive and reproducible diagnostic tool for bleeding disorders.
- The MBT assay allows for in vitro drug evaluation.