Related Experiment Video

Updated: Sep 18, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.8K

Prevalence of hypertension in pediatric-onset multiple sclerosis and associations with disease course: A case-control

Darina Dinov1, Alexia Richie2, Brenna Kent3

  • 1Division of Child Neurology, Department of Neurology, Children's Hospital of Richmond, VCU Health System, Richmond, VA, USA.

Multiple Sclerosis and Related Disorders
|June 22, 2025
PubMed

Insights

Pediatric-onset multiple sclerosis (MS) is linked to a higher prevalence of hypertension (HTN). This comorbidity in youth with MS may increase the risk of inflammatory lesion development.

Area of Science:

  • Neurology
  • Pediatrics
  • Cardiology

Background:

  • Adults with multiple sclerosis (MS) exhibit increased hypertension (HTN) rates, correlating with greater disability.
  • The prevalence and impact of HTN in pediatric-onset MS (POMS) remain largely uncharacterized.

Purpose of the Study:

  • To determine the prevalence of HTN in individuals with POMS.
  • To investigate the association between HTN and disease activity in POMS.

Main Methods:

  • A multicenter retrospective study compared blood pressure (BP) in individuals with POMS (iwPOMS) against matched controls.
  • Hypertension was defined using American Academy of Pediatrics guidelines based on at least three elevated BP recordings.
  • Disease activity was assessed via neutrophil-to-lymphocyte ratio and new T2-hyperintense lesions on MRI.

Main Results:

  • The study included 96 iwPOMS and 96 controls, revealing a significantly higher HTN prevalence in iwPOMS (22%) compared to controls (6%).
  • iwPOMS demonstrated elevated systolic BP at baseline and longitudinally at 12 and 24 months.
  • A higher incidence of new T2-hyperintense lesions was observed at 24 months in iwPOMS with HTN.

Conclusions:

  • Individuals with POMS have a greater prevalence of hypertension compared to matched controls.
  • The co-occurrence of HTN in youth with MS may elevate the risk for developing inflammatory lesions.
Abstract

Keywords:
AdolescentBody mass indexHypertensionInflammationMetabolic syndromeMultiple sclerosisPediatricSystolic

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.2K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.2K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
59
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
90
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
89
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
50
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
5.1K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.1K