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Updated: Sep 18, 2025
13:56
A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
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SARS-CoV-2 host-pathogen interactome: insights into more players during pathogenesis.
S A Mothae1, T E Chiliza2, N E Mvubu1
1School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.
Virology
|June 22, 2025
Summary
This review explores how SARS-CoV-2 (COVID-19) interacts with host proteins to replicate and spread. Understanding these interactions is key to developing new antiviral therapies and vaccines against coronaviruses.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- SARS-CoV-2 caused a global pandemic with millions of deaths.
- Viruses, including SARS-CoV-2, depend on host cell machinery for their life cycle.
- Understanding viral-host interactions is crucial for developing effective treatments.
Purpose of the Study:
- To review the SARS-CoV-2 host-pathogen interactome.
- To identify critical viral and host protein interactions during pathogenesis.
- To uncover potential therapeutic and vaccine targets for COVID-19 and future coronavirus outbreaks.
Main Methods:
- This study is a narrative review.
- It synthesizes existing research on SARS-CoV-2-host interactions.
- It focuses on protein-protein interactions and their roles in viral pathogenesis.
Main Results:
- SARS-CoV-2 utilizes host ACE2 and co-receptors for cell entry.
- The virus disrupts the host's type I interferon pathway to evade immunity.
- Viral proteins interact with host machinery for replication, assembly, and release, including lipid droplets, ER, and mitochondria.
Conclusions:
- The SARS-CoV-2 host-pathogen interactome presents numerous targets for antiviral strategies.
- Identifying key interactions can guide the development of novel therapeutics and vaccines.
- This knowledge is vital for preparedness against future coronavirus pandemics.
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