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New iboga-type indole alkaloids with anti-glioma activity from Tabernaemontana pachysiphon
Wen Gao1, Shangpeng Wu1, Haiyin Wang1
1School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Abstract:
Two novel oxidized iboga-type indole alkaloids 3-hydroxymethyl conopharyngine (1) and 6-oxoconopharyngine (2) were isolated from the fruits of Tabernaemontana pachysiphon. Their structures were elucidated through comprehensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Both compounds demonstrated potential anti-glioma activity by inhibiting the proliferation of glioma cells SH-HY5Y with IC50 values of 298.24-579.41 μmol/L, although without a clear dose-dependent effect.
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