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Updated: Sep 18, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Difunctionalization of Sulfamate-Derived Cyclic Imines through Phosphine Catalysis
Yaping Wang1, Bing Zheng1, Jiawei Liu1
1Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, People's Republic of China.
None:
With the use of alkynyl 1,2-diones as phosphine acceptors and H2O as a reaction partner, an unprecedented phosphine-catalyzed three-component difunctionalization of sulfamate-derived cyclic imines was achieved, providing a wide range of highly functionalized cyclic sulfonamide products in moderate to good yields. This protocol features a broad substrate scope and mild reaction conditions. It also represents a rare example of H2O serving as a substrate to participate in phosphine-catalyzed reactions. The reaction mechanism involves a tandem acyloxylation/cinnamoylation reaction.
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