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Updated: Sep 18, 2025
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
[Irritable bowel syndrome]
1Service de gastroentérologie, hôpital Avicenne, AP-HP, Bobigny, France ; Université Sorbonne Paris Nord et INSERM U-987, physiopathologie et pharmacologie clinique de la douleur ; hôpital Ambroise Paré, Boulogne-Billancourt, France.
Irritable bowel syndrome (IBS) is a common functional digestive disorder impacting quality of life. Management involves clinical diagnosis and various therapeutic strategies to improve symptoms and reduce severity.
Area of Science:
- Gastroenterology
- Digestive Health
Background:
- Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder.
- Affects 4-10% of the population, with a higher incidence in females.
- While benign, IBS can significantly reduce quality of life, especially in severe cases.
Purpose of the Study:
- To outline the diagnostic approach to IBS.
- To review current and emerging therapeutic strategies for IBS management.
- To emphasize the importance of understanding IBS mechanisms for effective treatment.
Main Methods:
- Diagnosis is primarily clinical, based on symptom assessment.
- Limited complementary examinations are used for differential diagnosis.
- Therapeutic strategies are informed by an improved understanding of IBS pathophysiology.
Main Results:
- Antispasmodics and transit modifiers are commonly employed treatments.
- Dietary modifications, probiotics, and physical activity show efficacy.
- Alternative therapies like hypnosis and therapeutic education can alleviate IBS symptoms.
Conclusions:
- Effective IBS management relies on clinical diagnosis and tailored therapeutic interventions.
- A multi-faceted approach combining medication, diet, lifestyle, and alternative therapies improves patient outcomes.
- Continued research into IBS mechanisms is crucial for developing novel treatments.
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