[Cytogenetic consequences of hyperbaric oxygenation in the sequence of cell cycles of human peripheral blood...

High pressure of oxygen induces chromosomal rearrangements in metaphases of human peripherical blood cells treated in vitro. An increase in the percentage of rearrangements was detected in the third mitosis, due mainly to chromatid breaks. The data of cytogenetical analysis of lymphocytes of human blood treated in vivo at 3 ata for 30 min are presented. A differential character of distribution spectrum of chromosomal aberrations induced after in vivo and in vitro treatment was noted. Some unusual alterations in chromosome morphology are described, namely, solid, not stained clear lense-like bodies surrounded by chromatin and localised in the long arm of chromatids.