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The 'autoimmunome' of centenarians

Pedro Carrera-Bastos^1,2,3, Abel Plaza-Florido⁴, Alejandro Santos-Lozano^5,6

¹Faculty of Biomedical and Health Sciences. Universidad Europea de Madrid, Madrid, Spain.

Journal of Translational Autoimmunity

|June 23, 2025

Abstract

Objective:

To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians.

Methods:

We conducted in silico data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases.

Results:

Sixteen autoimmune disease-related proteins were identified within the proteomic signatures of centenarians. Albumin was the most connected hub protein, notably elevated in centenarians compared to younger controls, suggesting a protective role. Eight of the identified autoimmunity-related proteins-ADIPOQ, C1S, C5, C7, C9, CFD, MASP1, and SERPING1-were associated with the complement system.

Conclusion:

Elevated albumin levels and a prominent complement system presence in centenarians' blood proteome may contribute to resistance to autoimmunity, highlighting potential protective mechanisms against autoimmune diseases in extreme longevity.

Keywords:

Aging Autoimmunity Centenarians Complement system Longevity Protein-protein interaction

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