Related Experiment Video
Updated: May 8, 2026

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
Published on: September 12, 2018
Exerkine GPLD1 bridges liver and brain
Abel Plaza-Florido1, Pedro Carrera-Bastos2, Alejandro Lucia3
1Research Center for Exercise Medicine and Sleep/Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Abstract:
A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer's-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain resilience.
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