Related Experiment Video
Updated: Sep 18, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
The 'autoimmunome' of centenarians.
Pedro Carrera-Bastos1,2,3, Abel Plaza-Florido4, Alejandro Santos-Lozano5,6
1Faculty of Biomedical and Health Sciences. Universidad Europea de Madrid, Madrid, Spain.
Centenarians show unique blood protein profiles, including higher albumin and complement system proteins, potentially explaining their resistance to autoimmune diseases and promoting longevity.
Area of Science:
- Proteomics
- Immunology
- Gerontology
Background:
- Autoimmune diseases are a significant health concern.
- Understanding resistance to autoimmunity is crucial for longevity research.
Purpose of the Study:
- To identify specific blood proteins associated with resistance to autoimmunity in centenarians.
- To explore potential protective mechanisms against autoimmune diseases in extreme longevity.
Main Methods:
- In silico data mining of existing proteomic datasets.
- Utilized STRING and PHENOPEDIA databases for analysis.
Main Results:
- Identified 16 autoimmune disease-related proteins in centenarians' blood.
- Albumin was a key hub protein, elevated in centenarians.
- Eight proteins (ADIPOQ, C1S, C5, C7, C9, CFD, MASP1, SERPING1) linked to the complement system were identified.
Conclusions:
- Elevated albumin and complement system proteins may confer resistance to autoimmunity.
- These findings suggest protective mechanisms contributing to extreme longevity.
More Related Videos
11:12Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
Published on: April 11, 2019
08:49Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
Published on: October 6, 2023
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Cells of the Adaptive Immune Response
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cell-mediated Immune Responses