Sciatic Nerve Neuropathy Secondary to Sacral Pressure Ulcer Following COVID-19: A Case Report

We report the case of a previously healthy 25-year-old man who developed severe SARS-CoV-2 infection requiring prolonged mechanical ventilation. Following extubation, he presented with peripheral sensory deficits and a sacral pressure ulcer. He was later admitted to our service with fever and a Grade IV ulcer, which required surgical debridement, negative pressure wound therapy, and definitive reconstruction using a V-Y gluteal flap. Examination of the right leg at admission demonstrated a neuropathic pain pattern, with neurological evaluation and imaging confirming distal sensorimotor polyneuropathy and chronic proximal sciatic neuropathy. Treatment with pregabalin led to complete resolution of symptoms, with no neurological deficit or residual pain identified during follow-up. This report suggests a plausible intersection between pressure-related and neurological complications in critically ill COVID-19 patients and highlights the importance of early preventive strategies such as frequent repositioning and multidisciplinary ICU care.