A novel model describing blood pressure profiles.

Area of Science:

• Cardiology
• Biomedical Engineering
• Chronobiology

Background:

• Blood pressure exhibits a circadian rhythm, typically rising in the morning and falling at night.
• Deviations from normal blood pressure patterns are linked to increased cardiovascular risk.
• Analyzing blood pressure profiles and variability is crucial for risk assessment.

Purpose of the Study:

• To develop a novel model for visualizing blood pressure profiles over several days.
• To enable the assessment of intra- and inter-individual blood pressure variability.
• To analyze circadian patterns in blood pressure using cuffless measurement data.

Main Methods:

• A blood pressure model was created using cuffless measurements from six healthy volunteers over 14 days.
• Exponential formulas described systolic and diastolic blood pressure curves.
• A non-linear regression model in R was employed for data analysis.

Main Results:

• All subjects demonstrated a clear circadian pattern in both systolic and diastolic blood pressure.
• Blood pressure was consistently lower during nighttime hours compared to daytime for all participants.
• Individual differences in blood pressure levels, fluctuation, and sleep times were observed, highlighting unique daily curves.

Conclusions:

• The developed model effectively visualizes multi-day blood pressure profiles.
• It allows for the assessment of both within-subject and between-subject blood pressure variability.
• This tool aids in understanding individual blood pressure dynamics and potential cardiovascular risk factors.