Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
Tumor Progression02:07

Tumor Progression

6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative Assessment of the Correlation Between 'COVID Toes' Search Volume and COVID-19 Case Incidence and Mortality Dynamics: A Longitudinal Data-Driven Approach.

Journal of the American Podiatric Medical AssociationĀ·2026
Same author

Rewiring immunity: CAR-T cells as a paradigm shift in hematologic oncology.

Critical reviews in oncology/hematologyĀ·2026
Same author

Poseidon's Trident: "Divine" Intervention in Cervical Cancer Through Chemoradiation, Immunotherapy, and Antibody-Drug Conjugates.

CancersĀ·2026
Same author

Unmasking the microbiome: the hidden role of gut bacteria in the pathogenesis of colorectal cancer and its prevention strategies.

Exploration of targeted anti-tumor therapyĀ·2025
Same author

Exploring the Tumor Microenvironment in Osteosarcoma: Driver of Resistance and Progression.

CancersĀ·2025
Same author

Beyond Detection: Conventional and Emerging Biomarkers in Gastrointestinal Cancers.

CancersĀ·2025

Related Experiment Video

Updated: Sep 18, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.3K

Osteosarcoma: current insights and advances.

Guraustin S Brar1, Aidan A Schmidt1, Logan R Willams2

  • 1Department of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.

Exploration of Targeted Anti-Tumor Therapy
|June 23, 2025
PubMed
Summary

Osteosarcoma, a primary bone cancer in young adults, has a poor prognosis due to aggressive metastasis. This review details current treatments and emerging therapies like gene therapy and immunotherapy to improve outcomes.

Keywords:
Osteosarcomagene therapyimmunotherapyradiationtyrosine kinase inhibitors

More Related Videos

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.3K
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

9.9K

Related Experiment Videos

Last Updated: Sep 18, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.3K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.3K
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

9.9K

Area of Science:

  • Oncology
  • Orthopedic Oncology

Background:

  • Osteosarcoma is the most common primary malignant bone tumor in adolescents and young adults.
  • Poor prognosis is linked to aggressive behavior and frequent metastasis at diagnosis.
  • Etiology is multifactorial, including genetic, environmental, and familial factors.

Purpose of the Study:

  • To provide a comprehensive overview of osteosarcoma.
  • To discuss current and evolving treatment modalities.
  • To highlight recent therapeutic innovations and future research directions.

Main Methods:

  • Comprehensive literature review.
  • Synthesis of current research on osteosarcoma.
  • Analysis of historical context, classifications, diagnostics, and treatments.

Main Results:

  • Neoadjuvant chemotherapy and surgical resection are standard treatments.
  • Emerging therapies include gene therapy, immunotherapy, advanced radiation, and tyrosine kinase inhibitors.
  • Significant challenges remain in improving patient outcomes.

Conclusions:

  • Despite advancements, osteosarcoma prognosis remains challenging.
  • Novel therapeutic strategies show promise for improving patient survival.
  • Further research is critical to address knowledge gaps and enhance osteosarcoma care.