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Insights on pediatric medication initiation: perceptions of caregivers and children
Maria Rubio-Valera1,2,3,4, Cristina Carbonell-Duacastella1,3, Maite Peñarrubia-María3,5,6
1Health Technology Assessment in Primary Care and Mental Health (PRISMA) Research Group, Teaching, Research and Innovation Unit, Institut de Recerca Sant Joan de Déu, de Llobregat, Spain.
Insights
Caregiver perceptions of disease and medication risks, along with healthcare system factors, influence pediatric medication initiation. Shared decision-making involving children and supporting caregivers can improve treatment adherence.
Area of Science:
- Pediatric pharmacology
- Health decision-making
- Qualitative research
Background:
- A significant proportion of prescribed medications are not initiated for children.
- Understanding the motivations behind non-initiation is crucial for improving pediatric treatment adherence.
Purpose of the Study:
- To explore factors influencing the decision to initiate medication in children.
- To understand these factors from the perspectives of both caregivers and children.
Main Methods:
- Qualitative study employing Grounded theory with a constructivist approach.
- Semi-structured interviews conducted with 21 caregivers and 6 children in Spain (2021-2022).
- Constant comparative analysis of transcribed interviews by pharmacists, pediatricians, and family physicians.
Main Results:
- Caregivers (primarily mothers) are central to treatment initiation decisions, rarely involving children.
- Decisions are based on risk-benefit evaluations influenced by perceptions of disease/medication, intrapersonal factors, child-related factors, professional interactions, healthcare system trust, and contextual influences (e.g., media, stigma).
- Healthcare professionals' accessibility, communication, respect, and support significantly impact caregiver decisions.
Conclusions:
- Pediatric medication initiation is multifactorial, involving perceptions, intrapersonal, interpersonal, healthcare system, and contextual factors.
- Shared decision-making, incorporating children's input and addressing caregiver support needs, is essential for promoting treatment initiation.
Introduction:
Children fail to initiate a high proportion of medications but little is known about motivations for non-initiation.
Objective:
To explore the factors affecting the decision to initiate a medication prescribed to children from caregivers' and children's perspectives.
Methods:
Qualitative study based on Grounded theory using a constructivist approach. Twenty-one caregivers and six children (<18 years old) were individually interviewed between 2021 and 2022 in Spain using a semi-structured thematic guide. Interviews were transcribed and analyzed by pharmacists, pediatricians and family physicians through a constant comparative analysis and results were internally audited.
Results:
Caregivers and healthcare professionals are the central figures involved in the decision-making process regarding treatment initiation; children were rarely involved. Caregivers, usually mothers, made a risk-benefit evaluation based on the perception of the disease and the medication, which was influenced by intrapersonal factors (emotional burden, health literacy and stigma); children-related factors (age, treatment and emotional burden); and factors related to the professionals (accessibility, discourse alignment, information, respect and emotional support, trust and specialty); healthcare system (trust and use of e-consultations) and context (media, peer pressure and social stigma).
Conclusion:
The decision to initiate medication in the pediatric population is multifactorial and influenced by perceptions on the disease and treatment, intrapersonal factors related to the caregivers and children, and interpersonal factors and factors related to the healthcare system and contexts. An informed, shared decision-making process that considers both the participation of children and the needs for support from caregivers when prescribing a treatment could promote initiation in the pediatric population.
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