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Updated: Sep 18, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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Ras homolog enriched in brain 1 regulates β cell mass and β cell function via mTORC1/AMPK/Notch1 pathways.

Yan Yang1, Wan-Juan Song2, Jing-Jing Zhang3

  • 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.

World Journal of Diabetes
|June 23, 2025
PubMed
Summary

Ras homolog enriched in brain 1 (Rheb1) regulates beta cell proliferation and identity. This protein, Rheb1, is a promising therapeutic target for diabetes by influencing beta cell mass and function.

Keywords:
AMP-activated protein kinaseDiabetesHepatocyte nuclear factor4-alphaRheb1mTORβ cells

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