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Updated: Sep 18, 2025
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Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
Published on: May 18, 2015
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Esophageal Mucosal Injuries From Drugs, Radiation, and Caustic Agents
Hyung Jin Bae1, Younghee Choe1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Summary
Esophageal mucosal injury from drugs, radiation, or caustic agents requires prompt identification and management. Avoiding the cause and using protective measures aids healing, but long-term monitoring is vital for preventing complications like strictures or cancer.
Area of Science:
- Gastroenterology
- Oncology
Background:
- Esophageal mucosal injury can result from various factors including medications, radiation therapy, and ingestion of caustic substances.
- Accurate diagnosis is essential for effective management and prevention of complications.
Purpose of the Study:
- To outline the diagnostic approaches and management strategies for esophageal mucosal injuries.
- To highlight the importance of identifying causative agents and implementing appropriate interventions.
Main Methods:
- Review of clinical features, patient history, and endoscopic findings for diagnosing esophageal injuries.
- Discussion of management principles including avoidance of offending agents and use of protective therapies.
Main Results:
- Esophageal injuries are often diagnosed clinically and endoscopically, frequently obviating the need for biopsies.
- Management focuses on removing the causative agent, with radiation dose modification if necessary.
- Mucosal protective agents and dietary modifications support epithelial regeneration.
Conclusions:
- Early identification and avoidance of inciting factors are key to managing esophageal mucosal injury.
- Chronic complications such as esophageal strictures necessitate ongoing surveillance.
- Caustic agent-induced injuries increase esophageal cancer risk, mandating long-term monitoring.
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