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Updated: Sep 18, 2025

Hyperpolarized Xenon for NMR and MRI Applications
Published on: September 6, 2012
Parahydrogen-induced hyperpolarization of a Zn(II) complex using NMR signal amplification by reversible exchange
Jisu Kim1, Hye Jin Jeong1, Sein Min1
1Department of Chemistry, Korea Military Academy, Seoul 01805, South Korea. doas1mind@kma.ac.kr.
Abstract:
Although Zn(II) complexes are critical metallobiomolecules in many biological environments, no parahydrogen-based hyperpolarization technique has been reported for such species. Herein, Zn(II)-tris(2-pyridylmethyl)amine (TPA) was hyperpolarized using NMR signal amplification by reversible exchange (SABRE) as a rapid, low-cost, portable, and repeatable technique for spin hyperpolarization. The hyperpolarization of TPA was not significantly affected by Zn(II) relaxation, whereas the polarization trends with respect to magnetic fields and Zn(II) concentrations differed from those of previous reports. The use of SABRE on metal complexes enables new NMR-based analytical and MRI applications. Thus, SABRE is a promising technique for a wide range of polarizable biomaterials.
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