Related Experiment Video
Updated: Sep 18, 2025
Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
Clonal haematopoiesis of indeterminate potential: a risk factor for future exacerbation in patients with COPD
Jung-Kyu Lee1, Hongyul An2, Youngil Koh2,3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Insights
Clonal hematopoiesis of indeterminate potential (CHIP) in COPD patients is linked to more acute exacerbations but not lung function decline. This finding suggests CHIP may indicate a poorer prognosis in COPD.
Area of Science:
- Pulmonary Medicine
- Hematology
- Genetics
Background:
- Limited data exists on the clinical significance of clonal hematopoiesis of indeterminate potential (CHIP) in chronic obstructive pulmonary disease (COPD).
- Investigating CHIP as a prognostic biomarker in COPD is crucial for understanding disease progression.
Purpose of the Study:
- To evaluate if CHIP serves as a biomarker for long-term prognosis in patients with COPD.
- To determine the association between CHIP and the risk of acute exacerbations and lung function changes.
Main Methods:
- Next-generation sequencing was employed to detect CHIP in peripheral blood mononuclear cells.
- A prospective observational cohort of 125 COPD patients was analyzed between January 2013 and December 2023.
- Negative binomial and linear mixed regression models assessed CHIP's association with acute exacerbations and lung function.
Main Results:
- CHIP was detected in 25.6% (32/125) of COPD patients.
- Higher smoking intensity and COPD Assessment Test scores correlated with CHIP positivity.
- CHIP positivity was associated with an increased risk of mild and total acute exacerbations, but not with lung function changes.
Conclusions:
- CHIP positivity in COPD patients is significantly associated with an increased risk of subsequent acute exacerbations.
- CHIP status did not demonstrate a statistically significant association with longitudinal changes in lung function.
- CHIP may serve as a prognostic biomarker for exacerbation risk in COPD.
Background:
There are limited data regarding the clinical significance of clonal haematopoiesis of indeterminate potential (CHIP) in patients with COPD. We aimed to evaluate whether CHIP could serve as a biomarker for the long-term prognosis of patients with COPD.
Methods:
Next-generation sequencing was used to detect CHIP in peripheral blood mononuclear cell samples. Participants with COPD were enrolled in a prospective observational cohort between January 2013 and December 2023. We investigated the association of CHIP status with the risk of subsequent acute exacerbation and longitudinal changes in lung function, by using negative binomial regression and linear mixed regression models, respectively.
Results:
Among 125 patients with COPD, the CHIP-positive group was 32 (25.6%). Higher smoking intensity and COPD Assessment Test score were significantly associated with increased risk of positive CHIP status, especially in current smokers. Positive CHIP of specific genes was significantly associated with a higher risk of subsequent mild and total acute exacerbation. Positive CHIP of ASXL transcriptional regulator 1 had a lower risk of subsequent total acute exacerbation (adjusted OR 0.19, 95% CI 0.04-0.95). CHIP status did not show a statistically significant association with longitudinal changes in lung function.
Conclusions:
In patients with COPD, CHIP positivity was significantly associated with an increased risk of subsequent acute exacerbations, but not with longitudinal changes in lung function.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:22Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:21Lineage Commitment